Idiosyncratic dapsone induced manic depression.

Brain mechanisms in manic depression.

Manic depressive illness (bipolar disorder) is the mood disorder classically considered to have a strong biological basis. During manic depressive cycles, patients show dramatic fluctuations of mood, energy, activity, information processing, and behaviors. Theories of brain function and mood disorders must deal with the case of bipolar disorder, not simply unipolar depression. Shifts in the nos...

Dapsone induced eosinophilic pneumonia.

Eosinophilic lung diseases (ELD) are a variety of several clinical entities, which may result from different etiologies, including drug treatment. Dapsone, a sulfone antibiotic widely used in leprosy (among other indications), has been described as a possible cause of ELD. We report a patient with leprosy who presented with respiratory symptoms and pulmonary infiltrates and was diagnosed as suf...

Brainstorm: Manic Depression, Occupational Choice And Creativity

Manic-depressive illness (bipolar disorder) afflicts approximately 2.3 million American adults. Although earnings, unemployment, and labor force participation patterns have been analyzed for manic-depressives in the economics literature, occupational choice has yet to be explored. A number of psychiatric studies link bipolar illness and occupational choice, focusing on occupational creativity. ...

Hemolysis and Anemia Induced by Dapsone Hydroxylamine

Dapsone-induced erythroderma with Beau's lines.

A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported. Sudden onset of erythroderma gave rise to a temporary arrest of the function of nail matrix with the resultant Beau's lines. She rapidly recovered with omission of dapsone and therapy with systemic corticosteroids and a topical emollient. In view of the potentially fatal hyp...